Vulnerability of immunosuppressed transplant recipients: what are the mechanisms underlying rejection and immune tolerance?

PI: Jonathan Visentin

We persue our longstanding investigations in transplant recipients in order to understand the mechanisms underlying graft rejection.

Our goal is a better understanding of B cell tolerance to discover novel pathways targetable to prevent graft rejection and graft versus host disease, and also novel biomarkers to guide clinical decision. We also want to characterize antibody response in transplantation through the analytical method we developed allowing evaluation of active concentration and affinity of anti-HLA antibodies. We also apply proteomic analysis by mass spectrometry in pathophysiological and diagnosis characterization of microvascular inflammation lesions in human kidney transplantation.

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