ImmunoConcEpT
The ImmunoConcEpT lab focuses on the immune system and its pathologies; it regroups most investigators involved in this field on the Bordeaux campus.
IMMUNOLOGY from CONCEPT and EXPERIMENTS to TRANSLATION
CNRS UMR 5164 – University of Bordeaux
News
ImmunoConcEpT à la NUIT EUROPEENNE DES CHERCHEUR.E.S

Fridolin Gross obtains ANR project

Jonathan Visentin interview on his experience as a Marie Sklodowska-Curie fellow in the USA is now online.

Maël Lemoine obtains ANR project

Congrats to Johan Garaude for the ANR award

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Upcoming Events
Christel Devaud, CRCT (Toulouse)
05/10/2023
Thursday Seminar: Simon Okholm
19/10/2023
PhD defence: Florent Guerville
20/10/2023
Thursday Seminar: BD BioSciences
26/10/2023
Thursday Seminar: Manju B. Joshi
02/11/2023
Seminar of Prof Mark J. Shlomchik
07/11/2023
Thursday Seminar: Team 2
09/11/2023
Thursday Seminar: Domitile Chalopin
16/11/2023
Thursday Seminar: Team4
23/11/2023
Thursday Seminar: Ludovic Martinet (Toulouse)
30/11/2023
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Découvrir ImmunoConcept
As we try to make our understandable to non-scientice people, we made a section to explain our work in an easy way.
Medical research
Several members of our lab are physicians in Medicine fields involving immunological or immunology-related physiopathologies.
Immunoconcept
Latest News
ImmunoConcEpT’s fresque du climat
We had our first “la Fresque du Climat” at ImmunoConcEpT which was animated by a colleague from the MFP lab. Many thanks to her!
Immunoconcept
Upcoming Events
Christel Devaud, CRCT (Toulouse)
05/10/2023
Christel Devaud is a former PhD student of Myriam Capone.
After a post-doctoral experience in Australia, she joined the “Centre de Recherches en Cancérologie” in Toulouse, where she works now as an Inserm researcher (CRCN).
Thursday Seminar: Simon Okholm
19/10/2023
Simon Okholm (Team 4) will present his PhD project about “Geroscience”.
PhD defence: Florent Guerville
20/10/2023
“Inflammation, aging and chronic diseases: implication of inflammasomes”.
(The defence will be in french)
Thursday Seminar: BD BioSciences
26/10/2023
Thursday Seminar: Manju B. Joshi
02/11/2023
Seminar of Prof Mark J. Shlomchik
07/11/2023
Autoimmunity research: We are using genetically modified mouse models to address the roles of specific cell types (e.g. B cells, T cells and DCs) in systemic autoimmunity. Currently we are particularly interested in the identity and function of autoreactive T cells that help autoreactive B cells and that infiltrate target tissues using novel TCR cloning methods. A second major area is investigating the regulatory role of TLR9 and stimulatory role of TLR7 in lupus, and to define how TLRs function in tissue-specific fashion. To this end we have made conditional alleles of both TLR7 and TLR9 on a lupus-prone mouse genetic background and we are dissecting the tissue-specific roles of these receptors. We have also introduced key point mutants and chimeric molecules into the germline of this mouse strain to test hypothesis about function in vivo and in signaling assays in vitro. Finally, we continue to work on the role of B cells in lupus and how best to therapeutically target them.
B cell immunity: we are investigating the mechanisms of cellular selection and differentiation in the germinal center (GC), a site of rapid proliferation, mutation, and differentiation into memory B cells (MBC). We recently showed that the GC shifts its output from MBC to plasma cells as it matures with time. We are actively working on “non-canonical” extrafollicular B cell responses, which induce isotype switch and mutation outside of GC as well as generate MBC; a key question is what controls the choice between these two types of response. We have also identified novel subsets of MBC in mice and are studying their origins and function using epigenetic, single cell, and subpopulation gene expression analysis. Our work on MBC has now been extended to humans, where, by studying multiple lymphoid and mucosal tissues, we have identified novel populations of MBC.
Thursday Seminar: Team 2
09/11/2023
Thursday Seminar: Domitile Chalopin
16/11/2023
Thursday Seminar: Team4
23/11/2023
Thursday Seminar: Ludovic Martinet (Toulouse)
30/11/2023
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