Immunology of Cancer and Inflammatory Diseases
Cancer control is intricately linked to the potency of immune responses. The research objective of our team is to understand the immunology of cancer with a specific focus on the mechanisms of cancer immune escape towards the development of novel biomarkers to stratify patients and to develop novel immunotherapies.
- Head : Nicolas Larmonier and Charlotte Domblides
- Univ. Bordeaux, CNRS UMR5164
Discover
The research objective of our team is to fine map the landscape of the innate immune compartment, with a focus on myeloid cells, in cancer and inflammatory diseases. We wish to study their phenotypes and functions in cancer initiation, promotion and metastasis, immune suppression and evasion, anti-tumor immunity, as well as irAEs in response to immunotherapies. We are particularly interested in a) the role of innate immunity receptors e.g. inflammasomes in priming anti-tumor immune responses, b) the impact of metabolic crosstalk between cancer cells and myeloid cells and the role of immunometabolism in driving myeloid cell phenotypes and functions, c) the cross-talk between myeloid cells and cancer stem cells in cancer stemness and promotion; d) the role of cancer-myeloid cells circulating clusters in cancer dissemination. Another axis of our team is centered on understanding the role of the intestinal and local microbiome in tumorigenesis and inflammatory reactions and the impact of co-medications on the composition and function of the microbiome in these processes. Our long term goal is to develop new therapeutic approaches that exploit the innate immune system and the microbiome to improve patient care.
The impact of immunometabolism in cancer and inflammatory diseases
The landscape and functions of innate immune cells in the tumor microenvironment and their role in immunotherapies
The role of the pharmaco-microbiome in cancer, irAEs and inflammatory diseases
Team Members
Publications
- Domblides, C, Crampton, S, Liu, H, Bartleson, JM, Nguyen, A, Champagne, C et al.. Human NLRC4 expression promotes cancer survival and associates with type I interferon signaling and immune infiltration. J Clin Invest. 2024;134 (11):. doi: 10.1172/JCI166085. PubMed PMID:38652550 PubMed Central PMC11142746.
- Giraud, J, Chalopin, D, Ramel, E, Boyer, T, Zouine, A, Derieppe, MA et al.. THBS1+ myeloid cells expand in SLD hepatocellular carcinoma and contribute to immunosuppression and unfavorable prognosis through TREM1. Cell Rep. 2024;43 (2):113773. doi: 10.1016/j.celrep.2024.113773. PubMed PMID:38350444 .
- Moisand, A, Madéry, M, Boyer, T, Domblides, C, Blaye, C, Larmonier, N et al.. Hormone Receptor Signaling and Breast Cancer Resistance to Anti-Tumor Immunity. Int J Mol Sci. 2023;24 (20):. doi: 10.3390/ijms242015048. PubMed PMID:37894728 PubMed Central PMC10606577.
- Domblides, C, Alizadeh, D, Larmonier, N. Editorial: Tumor-promoting immune cells: Cancer immune escape and beyond. Front Immunol. 2023;14 :1168884. doi: 10.3389/fimmu.2023.1168884. PubMed PMID:36936910 PubMed Central PMC10022880.
- Markarian, NM, Galli, G, Patel, D, Hemmings, M, Nagpal, P, Berghuis, AM et al.. Identifying Markers of Emerging SARS-CoV-2 Variants in Patients With Secondary Immunodeficiency. Front Microbiol. 2022;13 :933983. doi: 10.3389/fmicb.2022.933983. PubMed PMID:35847101 PubMed Central PMC9283111.
- Torri, A, Jaeger, J, Pradeu, T, Saleh, MC. The origin of RNA interference: Adaptive or neutral evolution?. PLoS Biol. 2022;20 (6):e3001715. doi: 10.1371/journal.pbio.3001715. PubMed PMID:35767561 PubMed Central PMC9275709.