Origins and pathogenesis of Autoimmune and Inflammatory disorders

The aim of our group is to better understand the origination and development of autoimmune and autoinflammatory disorders (AID). Using observational studies in patient cohorts along with in vitro and in vivo experiences in the lab, we strive to better understand the functional specificities behind these diseases in order to improve diagnosis and treatment options for patients.

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The term autoimmune and autoinflammatory disorders (AID) encompasses a large number of conditions that have in common a dysregulation of the immune system. Most AIDs are chronic diseases for which a cure does not yet exist, but their progression can be slowed down. Therefore our team works on two complementary strategies: Identifying markers for the earliest stages of the disease, in order to delay their evolution as much as possible, and characterize the underlying mechanisms of the disease, to open up new therapeutic avenues.
The members of our group have expertise in different AIDs such as lupus, systemic sclerosis, vitiligo and multiple sclerosis. Collectively they have long standing experience in fundamental, translational and clinical research. The group is organized in 5 researches axes:
• T-cell dependent B-cell activation in the model of Lupus.
• Inflammation and fibrosis in human pathophysiology
• Crosstalk between immune and epidermal cells
• DNA sensing
• Gut derived T-cells

The different axes each use their own disease model and together they present an in depth analysis of the immune system and its possible malfunctions.

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