Cancer as a cause or consequence of immune vulnerability

PI: Julie Déchanet-Merville

Cancer in another pathological model we are using to understans the important role of T lymphocytes.

In collaboration with the SIRIC Brio, we apply deep phenotyping of αβ and γδ T cells in old cancer patients. We also perform a comprehensive characterization of the phenotype and functions of γδ T cells in glioblastoma (GBM) patients and try to develop a γδ T cell based therapy to treat these patients. We are also identifying the molecular mechanisms – including tumor antigens recognised by γδ TCRs – involved in tumor cell recognition by γδ T cells.

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