CR - INSERM
Vulnerability and ageing of the immune system
About Johan Garaude
ORCID id : 0000-0001-7789-7715
I got my Ph.D. in Moleclular Endocrinology in 2007 from the University of Montpellier, France, for my work on mitogen-activated protein kinases (MAPK) and activating-protein 1 (AP-1) in leukemogenesis and T cell activation under the supervision of Dr. Martin Villalba (IGMM, CNRS). In 2008, I joined the laboratory of Dr. Julie Magarian Blander at the Mount Sinai School of Medicine in New York where I investigated how a dual ligand for innate immune receptors can be used to generate potent antitumor immune responses and contributed at establishing that the sensing of infected apoptotic cell by dendritic cells is a natural inducer of TH17 cell differentiation. In 2011, I got a permanent position (Chargé de Recherche) at INSERM, France, and started investigating the metabolic adaptations and mitochondrial biology in innate immune cells and how this contributes to antimicrobial responses. The same year, I started as a visiting scientist at CNIC (Centro Nacional de Investigaciones Cardiovasculares) in Madrid, Spain. In 2017, I finally moved back to France, in Bordeaux, and worked for a time at MRGM (Maladies Rares: Génétique et Métabolisme, INSERM U1211) before joining ImmunoConcept (INSERM ERL1303, CNRS 5164) where I continue to investigate the metabolism of host-pathogen interactions and mitochondrial biology in the innate immune system.
My research / PhD / Post-doc / projects
Innate Immunity, Mitochondria, Metabolism, Mitochondrial diseases, Host-Pathogen interaction, Pathogen Recognition Receptors